STRING 9.1 
  ARRB2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ARRB2
arrestin, beta 2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (409 aa)
(Homo sapiens)
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
     0.999
MDM2
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
      0.999
ARF6
ADP-ribosylation factor 6; GTP-binding protein that functions as an allosteric activator of the [...] (175 aa)
     0.987
MAPK1
mitogen-activated protein kinase 1; Involved in both the initiation and regulation of meiosis, [...] (360 aa)
     0.987
MAP3K5
mitogen-activated protein kinase kinase kinase 5; Component of a protein kinase signal transduc [...] (1374 aa)
      0.985
DVL2
dishevelled, dsh homolog 2 (Drosophila); May play a role in the signal transduction pathway med [...] (736 aa)
     0.983
TGFBR3
transforming growth factor, beta receptor III; Binds to TGF-beta. Could be involved in capturin [...] (851 aa)
     0.981
ADRB2
adrenergic, beta-2-, receptor, surface; Beta-adrenergic receptors mediate the catecholamine- in [...] (413 aa)
     0.981
MAP2K4
mitogen-activated protein kinase kinase 4; Dual specificity kinase that activates the JUN kinas [...] (399 aa)
     0.979
CXCR4
chemokine (C-X-C motif) receptor 4; Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a [...] (356 aa)
    0.974
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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