node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP15 | FIGLA | ENSP00000252677 | ENSP00000333097 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | 0.955 |
BMP15 | OOSP1 | ENSP00000252677 | ENSP00000494485 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. | Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family. | 0.446 |
BMP15 | OOSP2 | ENSP00000252677 | ENSP00000278855 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. | Oocyte secreted protein 2. | 0.424 |
BMP15 | ZP4 | ENSP00000252677 | ENSP00000482304 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. | Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. | 0.687 |
C21orf62 | OOSP2 | ENSP00000418653 | ENSP00000278855 | Uncharacterized protein C21orf62; Chromosome 21 open reading frame 62. | Oocyte secreted protein 2. | 0.434 |
FIGLA | BMP15 | ENSP00000333097 | ENSP00000252677 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. | 0.955 |
FIGLA | OOSP2 | ENSP00000333097 | ENSP00000278855 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Oocyte secreted protein 2. | 0.476 |
FIGLA | ZP4 | ENSP00000333097 | ENSP00000482304 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. | 0.769 |
MS4A18 | MS4A5 | ENSP00000431607 | ENSP00000300190 | Membrane spanning 4-domains A18. | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. | 0.532 |
MS4A18 | OOSP1 | ENSP00000431607 | ENSP00000494485 | Membrane spanning 4-domains A18. | Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family. | 0.506 |
MS4A18 | OOSP2 | ENSP00000431607 | ENSP00000278855 | Membrane spanning 4-domains A18. | Oocyte secreted protein 2. | 0.664 |
MS4A3 | OOSP2 | ENSP00000278865 | ENSP00000278855 | Membrane-spanning 4-domains subfamily A member 3; Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP); Belongs to the MS4A family. | Oocyte secreted protein 2. | 0.490 |
MS4A5 | MS4A18 | ENSP00000300190 | ENSP00000431607 | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. | Membrane spanning 4-domains A18. | 0.532 |
MS4A5 | OOSP2 | ENSP00000300190 | ENSP00000278855 | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. | Oocyte secreted protein 2. | 0.557 |
MS4A5 | OOSP4B | ENSP00000300190 | ENSP00000494382 | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. | Oocyte secreted protein family member 4B. | 0.695 |
OOSP1 | BMP15 | ENSP00000494485 | ENSP00000252677 | Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family. | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. | 0.446 |
OOSP1 | MS4A18 | ENSP00000494485 | ENSP00000431607 | Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family. | Membrane spanning 4-domains A18. | 0.506 |
OOSP1 | OOSP2 | ENSP00000494485 | ENSP00000278855 | Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family. | Oocyte secreted protein 2. | 0.708 |
OOSP1 | OOSP3 | ENSP00000494485 | ENSP00000495263 | Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family. | Oocyte secreted protein family member 3. | 0.583 |
OOSP1 | ZP4 | ENSP00000494485 | ENSP00000482304 | Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family. | Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. | 0.507 |