node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABLIM3 | AFAP1L1 | ENSP00000425394 | ENSP00000296721 | Actin-binding LIM protein 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | 0.546 |
ABLIM3 | GRPEL2 | ENSP00000425394 | ENSP00000329558 | Actin-binding LIM protein 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | 0.429 |
AFAP1L1 | ABLIM3 | ENSP00000296721 | ENSP00000425394 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Actin-binding LIM protein 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | 0.546 |
AFAP1L1 | CTTN | ENSP00000296721 | ENSP00000365745 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases. Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates co [...] | 0.560 |
AFAP1L1 | GADD45G | ENSP00000296721 | ENSP00000252506 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Growth arrest and DNA damage-inducible protein GADD45 gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK; Belongs to the GADD45 family. | 0.710 |
AFAP1L1 | GRPEL2 | ENSP00000296721 | ENSP00000329558 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | 0.663 |
AFAP1L1 | HCLS1 | ENSP00000296721 | ENSP00000320176 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. | 0.555 |
AFAP1L1 | RCBTB2 | ENSP00000296721 | ENSP00000389910 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | RCC1 and BTB domain containing protein 2. | 0.462 |
AFAP1L1 | RPH3AL | ENSP00000296721 | ENSP00000328977 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Rab effector Noc2; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. | 0.458 |
AFAP1L1 | SYT10 | ENSP00000296721 | ENSP00000228567 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). | 0.471 |
AFAP1L1 | TDRD5 | ENSP00000296721 | ENSP00000406052 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). | 0.462 |
AFAP1L1 | VPS53 | ENSP00000296721 | ENSP00000401435 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized tr [...] | 0.460 |
CTTN | AFAP1L1 | ENSP00000365745 | ENSP00000296721 | Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases. Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates co [...] | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | 0.560 |
GADD45G | AFAP1L1 | ENSP00000252506 | ENSP00000296721 | Growth arrest and DNA damage-inducible protein GADD45 gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK; Belongs to the GADD45 family. | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | 0.710 |
GRPEL2 | ABLIM3 | ENSP00000329558 | ENSP00000425394 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | Actin-binding LIM protein 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | 0.429 |
GRPEL2 | AFAP1L1 | ENSP00000329558 | ENSP00000296721 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | 0.663 |
GRPEL2 | RCBTB2 | ENSP00000329558 | ENSP00000389910 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | RCC1 and BTB domain containing protein 2. | 0.466 |
HCLS1 | AFAP1L1 | ENSP00000320176 | ENSP00000296721 | Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | 0.555 |
RCBTB2 | AFAP1L1 | ENSP00000389910 | ENSP00000296721 | RCC1 and BTB domain containing protein 2. | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | 0.462 |
RCBTB2 | GRPEL2 | ENSP00000389910 | ENSP00000329558 | RCC1 and BTB domain containing protein 2. | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family. | 0.466 |