STRING 10 
  LRRK2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
LRRK2
leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa)
(Homo sapiens)
Predicted Functional Partners:
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes [...] (854 aa)
      0.999
MSN
moesin; Probably involved in connections of major cytoskeletal structures to the plasma membran [...] (577 aa)
      0.999
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1; Regulates eIF4E activity by prev [...] (118 aa)
      0.998
MBP
myelin basic protein (197 aa)
      0.994
CDC37
cell division cycle 37 homolog (S. cerevisiae); Co-chaperone that binds to numerous kinases and [...] (378 aa)
      0.994
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)
      0.992
MAP1B
microtubule-associated protein 1B; Facilitates tyrosination of alpha-tubulin in neuronal microt [...] (2468 aa)
      0.988
ARFGAP1
ADP-ribosylation factor GTPase activating protein 1 (414 aa)
      0.980
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (245 aa)
      0.979
TUBA1A
tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, [...] (451 aa)
      0.975
 
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