INSR protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
insulin receptor; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src- homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the act [...] (1382 aa)
(Homo sapiens)
Predicted Functional Partners:
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)
protein tyrosine phosphatase, non-receptor type 1; Tyrosine-protein phosphatase which acts as a [...] (435 aa)
SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)
insulin receptor substrate 2; May mediate the control of various cellular processes by insulin (1338 aa)
growth factor receptor-bound protein 10 (594 aa)
growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surfa [...] (540 aa)
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (110 aa)
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (724 aa)
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)
suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)
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