STRINGSTRING
GPR137C GPR137C TXNDC16 TXNDC16 TMEM221 TMEM221 LRRC42 LRRC42 GPR157 GPR157 STYX STYX DDHD1 DDHD1 GPR108 GPR108 TMEM171 TMEM171 HAUS8 HAUS8 GPR107 GPR107
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR137CIntegral membrane protein GPR137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes; Belongs to the GPR137 family. (429 aa)    
Predicted Functional Partners:
TXNDC16
Thioredoxin domain containing 16.
   
  
 0.671
TMEM221
Transmembrane protein 221.
      
 0.629
LRRC42
Leucine-rich repeat-containing protein 42; Leucine rich repeat containing 42; Belongs to the LRRC42 family.
      
 0.567
GPR157
G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol- calcium second messenger; Belongs to the G-protein coupled receptor 2 family.
      
 0.558
STYX
Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis (By similarity).
   
  
 0.550
DDHD1
Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Belongs to the PA-PLA1 family.
   
  
 0.539
GPR108
G protein-coupled receptor 108.
      
 0.529
TMEM171
Transmembrane protein 171.
      
 0.529
HAUS8
HAUS augmin-like complex subunit 8; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
   
  
 0.525
GPR107
Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).
      
 0.519
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.