NR2E3 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

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nuclear receptor subfamily 2, group E, member 3; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression (410 aa)
(Homo sapiens)
Predicted Functional Partners:
cone-rod homeobox; Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstrea [...] (299 aa)
neural retina leucine zipper; Transcription factor which regulates the expression of several ro [...] (237 aa)
ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the [...] (792 aa)
nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional re [...] (614 aa)
G protein-coupled receptor kinase 7; Phosphorylates cone opsins thereby initiating their deacti [...] (553 aa)
orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense o [...] (297 aa)
paired box 6; Transcription factor with important functions in the development of the eye, nose [...] (436 aa)
DEAH (Asp-Glu-Ala-His) box polypeptide 30 (1194 aa)
potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes [...] (381 aa)
RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that pla [...] (282 aa)
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