STRING 9.1 
  NR2E3 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NR2E3
nuclear receptor subfamily 2, group E, member 3; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression (410 aa)
(Homo sapiens)
Predicted Functional Partners:
CRX
cone-rod homeobox; Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstrea [...] (299 aa)
      0.984
NRL
neural retina leucine zipper; Transcription factor which regulates the expression of several ro [...] (237 aa)
       0.930
RRM1
ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the [...] (792 aa)
       0.817
OTX2
orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense o [...] (297 aa)
      0.658
NR1D1
nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional re [...] (614 aa)
     0.669
PAX6
paired box 6; Transcription factor with important functions in the development of the eye, nose [...] (436 aa)
      0.646
GRK7
G protein-coupled receptor kinase 7; Phosphorylates cone opsins thereby initiating their deacti [...] (553 aa)
       0.659
DHX30
DEAH (Asp-Glu-Ala-His) box polypeptide 30 (1194 aa)
      0.644
NCOR1
nuclear receptor co-repressor 1; Mediates transcriptional repression by certain nuclear recepto [...] (2440 aa)
      0.629
KCMF1
potassium channel modulatory factor 1; Has intrinsic E3 ubiquitin ligase activity and promotes [...] (381 aa)
       0.632
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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