node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR5 | ACTR6 | ENSP00000243903 | ENSP00000188312 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | 0.630 |
ACTR5 | INO80B | ENSP00000243903 | ENSP00000233331 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | 0.998 |
ACTR5 | KAT5 | ENSP00000243903 | ENSP00000340330 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.907 |
ACTR5 | RUVBL1 | ENSP00000243903 | ENSP00000318297 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...] | 0.999 |
ACTR5 | SRCAP | ENSP00000243903 | ENSP00000262518 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | Helicase SRCAP; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch- mediated transcription. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.788 |
ACTR5 | TRRAP | ENSP00000243903 | ENSP00000352925 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...] | 0.913 |
ACTR6 | ACTR5 | ENSP00000188312 | ENSP00000243903 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | 0.630 |
ACTR6 | INO80B | ENSP00000188312 | ENSP00000233331 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | 0.704 |
ACTR6 | KAT5 | ENSP00000188312 | ENSP00000340330 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.609 |
ACTR6 | RUVBL1 | ENSP00000188312 | ENSP00000318297 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...] | 0.999 |
ACTR6 | SRCAP | ENSP00000188312 | ENSP00000262518 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | Helicase SRCAP; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch- mediated transcription. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.999 |
ACTR6 | TRRAP | ENSP00000188312 | ENSP00000352925 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Also involved in transcription act [...] | 0.596 |
ACTR6 | VPS72 | ENSP00000188312 | ENSP00000346464 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. | 0.888 |
ACTR6 | YEATS4 | ENSP00000188312 | ENSP00000247843 | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] | 0.886 |
INO80B | ACTR5 | ENSP00000233331 | ENSP00000243903 | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Belongs to the actin family. ARP5 subfamily. | 0.998 |
INO80B | ACTR6 | ENSP00000233331 | ENSP00000188312 | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | Actin related protein 6; Belongs to the actin family. ARP6 subfamily. | 0.704 |
INO80B | KAT5 | ENSP00000233331 | ENSP00000340330 | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.936 |
INO80B | PIH1D1 | ENSP00000233331 | ENSP00000262265 | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. | 0.476 |
INO80B | RUVBL1 | ENSP00000233331 | ENSP00000318297 | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively reg [...] | 0.999 |
INO80B | SRCAP | ENSP00000233331 | ENSP00000262518 | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle. | Helicase SRCAP; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch- mediated transcription. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.776 |