STRINGSTRING
DEFB104A DEFB104A DEFB103A DEFB103A DEFB105A DEFB105A DEFB1 DEFB1 DEFB4A DEFB4A DEFB106B DEFB106B DEFB107A DEFB107A DEFB104B DEFB104B DEFB108B DEFB108B DEFB106A DEFB106A DEFA1B DEFA1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
DEFB104ABeta-defensin 104; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Belongs to the beta-defensin family. (72 aa)    
Predicted Functional Partners:
DEFB103A
Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.
     
 0.982
DEFB105A
Beta-defensin 105; Has antibacterial activity.
   
 
 0.959
DEFB1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
     
 0.956
DEFB4A
Beta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells. Belongs to the beta-defensin family. LAP/TAP subfamily.
     
 0.952
DEFB106B
Beta-defensin 106; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2. Belongs to the beta-defensin family.
   
 
 0.951
DEFB107A
Beta-defensin 107; Has antibacterial activity.
   
 
 0.920
DEFB104B
Defensin beta 104B.
   
  
0.891
DEFB108B
Beta-defensin 108B; Has antibacterial activity.
     
 0.871
DEFB106A
Defensin beta 106A.
   
  
 0.849
DEFA1B
Neutrophil defensin 1; Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
     
 0.849
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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