node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRA2 | ANTXR1 | ENSP00000406367 | ENSP00000301945 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. | 0.430 |
ADGRA2 | ARHGEF17 | ENSP00000406367 | ENSP00000263674 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. | 0.467 |
ADGRA2 | CD248 | ENSP00000406367 | ENSP00000308117 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | Endosialin; May play a role in tumor angiogenesis. | 0.621 |
ADGRA2 | PLXDC1 | ENSP00000406367 | ENSP00000323927 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis. | 0.670 |
ADGRA2 | RASD2 | ENSP00000406367 | ENSP00000216127 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | GTP-binding protein Rhes; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination; Belongs to the small GTPase superfamily. RasD family. | 0.480 |
ANTXR1 | ADGRA2 | ENSP00000301945 | ENSP00000406367 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | 0.430 |
ANTXR1 | CD248 | ENSP00000301945 | ENSP00000308117 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. | Endosialin; May play a role in tumor angiogenesis. | 0.531 |
ANTXR1 | PLXDC1 | ENSP00000301945 | ENSP00000323927 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis. | 0.545 |
ARHGEF17 | ADGRA2 | ENSP00000263674 | ENSP00000406367 | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | 0.467 |
ARHGEF17 | CD248 | ENSP00000263674 | ENSP00000308117 | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. | Endosialin; May play a role in tumor angiogenesis. | 0.501 |
ARHGEF17 | PLXDC1 | ENSP00000263674 | ENSP00000323927 | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis. | 0.643 |
ARHGEF17 | RASD2 | ENSP00000263674 | ENSP00000216127 | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. | GTP-binding protein Rhes; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination; Belongs to the small GTPase superfamily. RasD family. | 0.557 |
CD248 | ADGRA2 | ENSP00000308117 | ENSP00000406367 | Endosialin; May play a role in tumor angiogenesis. | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | 0.621 |
CD248 | ANTXR1 | ENSP00000308117 | ENSP00000301945 | Endosialin; May play a role in tumor angiogenesis. | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. | 0.531 |
CD248 | ARHGEF17 | ENSP00000308117 | ENSP00000263674 | Endosialin; May play a role in tumor angiogenesis. | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. | 0.501 |
CD248 | PLXDC1 | ENSP00000308117 | ENSP00000323927 | Endosialin; May play a role in tumor angiogenesis. | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis. | 0.824 |
CD248 | RASD2 | ENSP00000308117 | ENSP00000216127 | Endosialin; May play a role in tumor angiogenesis. | GTP-binding protein Rhes; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination; Belongs to the small GTPase superfamily. RasD family. | 0.889 |
FAM47E-STBD1 | PLXDC1 | ENSP00000422067 | ENSP00000323927 | FAM47E-STBD1 readthrough. | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis. | 0.433 |
FBXL20 | PLXDC1 | ENSP00000264658 | ENSP00000323927 | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis. | 0.426 |
HIGD1B | PLXDC1 | ENSP00000253410 | ENSP00000323927 | HIG1 hypoxia inducible domain family member 1B. | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis. | 0.517 |