node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CENPI | ZNF71 | ENSP00000362018 | ENSP00000328245 | Centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle- stimulating hormone; Belongs to the CENP-I/CTF3 family. | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | 0.421 |
GCSAML | MTMR8 | ENSP00000446460 | ENSP00000363985 | Germinal center associated signaling and motility like. | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. In complex with MTMR9, negatively regulates autophagy. | 0.438 |
GCSAML | ZNF71 | ENSP00000446460 | ENSP00000328245 | Germinal center associated signaling and motility like. | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | 0.428 |
MTMR8 | GCSAML | ENSP00000363985 | ENSP00000446460 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. In complex with MTMR9, negatively regulates autophagy. | Germinal center associated signaling and motility like. | 0.438 |
MTMR8 | ZNF71 | ENSP00000363985 | ENSP00000328245 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. In complex with MTMR9, negatively regulates autophagy. | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | 0.465 |
TRIM28 | ZFP2 | ENSP00000253024 | ENSP00000354453 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 2 homolog; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. | 0.522 |
TRIM28 | ZNF71 | ENSP00000253024 | ENSP00000328245 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | 0.574 |
ZFP2 | TRIM28 | ENSP00000354453 | ENSP00000253024 | Zinc finger protein 2 homolog; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.522 |
ZFP2 | ZNF71 | ENSP00000354453 | ENSP00000328245 | Zinc finger protein 2 homolog; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | 0.430 |
ZNF69 | ZNF71 | ENSP00000345333 | ENSP00000328245 | Zinc finger protein 69. | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | 0.896 |
ZNF71 | CENPI | ENSP00000328245 | ENSP00000362018 | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | Centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle- stimulating hormone; Belongs to the CENP-I/CTF3 family. | 0.421 |
ZNF71 | GCSAML | ENSP00000328245 | ENSP00000446460 | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | Germinal center associated signaling and motility like. | 0.428 |
ZNF71 | MTMR8 | ENSP00000328245 | ENSP00000363985 | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. In complex with MTMR9, negatively regulates autophagy. | 0.465 |
ZNF71 | TRIM28 | ENSP00000328245 | ENSP00000253024 | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.574 |
ZNF71 | ZFP2 | ENSP00000328245 | ENSP00000354453 | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | Zinc finger protein 2 homolog; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. | 0.430 |
ZNF71 | ZNF69 | ENSP00000328245 | ENSP00000345333 | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation. | Zinc finger protein 69. | 0.896 |