node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARIH1 | C16orf72 | ENSP00000369217 | ENSP00000331720 | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | 0.655 |
ARIH1 | DDX6 | ENSP00000369217 | ENSP00000478754 | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.445 |
C16orf72 | ARIH1 | ENSP00000331720 | ENSP00000369217 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | 0.655 |
C16orf72 | DDX6 | ENSP00000331720 | ENSP00000478754 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.448 |
C16orf72 | HUWE1 | ENSP00000331720 | ENSP00000340648 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and pro [...] | 0.522 |
C16orf72 | METTL22 | ENSP00000331720 | ENSP00000371345 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN. Belongs to the methyltransferase superfamily. METTL22 family. | 0.480 |
C16orf72 | POLE3 | ENSP00000331720 | ENSP00000363286 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. | 0.487 |
C16orf72 | POLE4 | ENSP00000331720 | ENSP00000420176 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | DNA polymerase epsilon subunit 4; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.454 |
C16orf72 | RNASEH2A | ENSP00000331720 | ENSP00000221486 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Belongs to the RNase HII family. Eukaryotic subfamily. | 0.448 |
C16orf72 | RNASEH2B | ENSP00000331720 | ENSP00000337623 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. | 0.457 |
C16orf72 | RNASEH2C | ENSP00000331720 | ENSP00000308193 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | Ribonuclease H2 subunit C; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. | 0.471 |
C16orf72 | TMEM186 | ENSP00000331720 | ENSP00000331640 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | Transmembrane protein 186. | 0.514 |
DDX6 | ARIH1 | ENSP00000478754 | ENSP00000369217 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | 0.445 |
DDX6 | C16orf72 | ENSP00000478754 | ENSP00000331720 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | 0.448 |
HUWE1 | C16orf72 | ENSP00000340648 | ENSP00000331720 | E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and pro [...] | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | 0.522 |
METTL22 | C16orf72 | ENSP00000371345 | ENSP00000331720 | Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN. Belongs to the methyltransferase superfamily. METTL22 family. | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | 0.480 |
METTL22 | TMEM186 | ENSP00000371345 | ENSP00000331640 | Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN. Belongs to the methyltransferase superfamily. METTL22 family. | Transmembrane protein 186. | 0.456 |
POLE3 | C16orf72 | ENSP00000363286 | ENSP00000331720 | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72. | 0.487 |
POLE3 | POLE4 | ENSP00000363286 | ENSP00000420176 | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. | DNA polymerase epsilon subunit 4; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.999 |
POLE3 | RNASEH2A | ENSP00000363286 | ENSP00000221486 | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Belongs to the RNase HII family. Eukaryotic subfamily. | 0.417 |