node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSL4 | ASCL4 | ENSP00000339787 | ENSP00000345420 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Belongs to the ATP-dependent AMP-binding enzyme family. | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | 0.726 |
ACSL4 | GPATCH2 | ENSP00000339787 | ENSP00000355902 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Belongs to the ATP-dependent AMP-binding enzyme family. | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro. | 0.474 |
ACSL4 | GPX4 | ENSP00000339787 | ENSP00000346103 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Belongs to the ATP-dependent AMP-binding enzyme family. | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. Th [...] | 0.834 |
ARHGAP42 | ASCL4 | ENSP00000298815 | ENSP00000345420 | Rho GTPase-activating protein 42; May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle. | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | 0.428 |
ARHGAP42 | MAIP1 | ENSP00000298815 | ENSP00000295079 | Rho GTPase-activating protein 42; May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.520 |
ARHGAP42 | NEPRO | ENSP00000298815 | ENSP00000320251 | Rho GTPase-activating protein 42; May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle. | Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. | 0.489 |
ASCL2 | ASCL4 | ENSP00000332293 | ENSP00000345420 | Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | 0.409 |
ASCL2 | ID2 | ENSP00000332293 | ENSP00000234091 | Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] | 0.425 |
ASCL2 | TCF12 | ENSP00000332293 | ENSP00000388940 | Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). | 0.580 |
ASCL4 | ACSL4 | ENSP00000345420 | ENSP00000339787 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Belongs to the ATP-dependent AMP-binding enzyme family. | 0.726 |
ASCL4 | ARHGAP42 | ENSP00000345420 | ENSP00000298815 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | Rho GTPase-activating protein 42; May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle. | 0.428 |
ASCL4 | ASCL2 | ENSP00000345420 | ENSP00000332293 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. | 0.409 |
ASCL4 | GPATCH2 | ENSP00000345420 | ENSP00000355902 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro. | 0.405 |
ASCL4 | GPX4 | ENSP00000345420 | ENSP00000346103 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. Th [...] | 0.518 |
ASCL4 | ID2 | ENSP00000345420 | ENSP00000234091 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] | 0.680 |
ASCL4 | MAIP1 | ENSP00000345420 | ENSP00000295079 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.494 |
ASCL4 | NEPRO | ENSP00000345420 | ENSP00000320251 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. | 0.477 |
ASCL4 | PHF24 | ENSP00000345420 | ENSP00000242315 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | PHD finger protein 24. | 0.461 |
ASCL4 | TCF12 | ENSP00000345420 | ENSP00000388940 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development. | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). | 0.665 |
GPATCH2 | ACSL4 | ENSP00000355902 | ENSP00000339787 | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro. | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Belongs to the ATP-dependent AMP-binding enzyme family. | 0.474 |