node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBWD5 | FUNDC2 | ENSP00000371842 | ENSP00000358510 | COBW domain containing 5. | FUN14 domain containing 2; Belongs to the FUN14 family. | 0.431 |
CLIC2 | CMC4 | ENSP00000358460 | ENSP00000358496 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. | Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family. | 0.402 |
CLIC2 | FUNDC2 | ENSP00000358460 | ENSP00000358510 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. | FUN14 domain containing 2; Belongs to the FUN14 family. | 0.456 |
CLIC2 | RAB39B | ENSP00000358460 | ENSP00000358466 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. | Ras-related protein Rab-39B; Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic retic [...] | 0.535 |
CLIC2 | VBP1 | ENSP00000358460 | ENSP00000286428 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. | 0.443 |
CMC4 | CLIC2 | ENSP00000358496 | ENSP00000358460 | Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family. | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. | 0.402 |
CMC4 | FUNDC2 | ENSP00000358496 | ENSP00000358510 | Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family. | FUN14 domain containing 2; Belongs to the FUN14 family. | 0.594 |
CMC4 | VBP1 | ENSP00000358496 | ENSP00000286428 | Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family. | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. | 0.492 |
CXorf56 | FUNDC2 | ENSP00000441786 | ENSP00000358510 | UPF0428 protein CXorf56; Chromosome X open reading frame 56. | FUN14 domain containing 2; Belongs to the FUN14 family. | 0.466 |
FAM162A | FUNDC2 | ENSP00000419088 | ENSP00000358510 | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. | FUN14 domain containing 2; Belongs to the FUN14 family. | 0.421 |
FUNDC1 | FUNDC2 | ENSP00000367284 | ENSP00000358510 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. | FUN14 domain containing 2; Belongs to the FUN14 family. | 0.667 |
FUNDC2 | CBWD5 | ENSP00000358510 | ENSP00000371842 | FUN14 domain containing 2; Belongs to the FUN14 family. | COBW domain containing 5. | 0.431 |
FUNDC2 | CLIC2 | ENSP00000358510 | ENSP00000358460 | FUN14 domain containing 2; Belongs to the FUN14 family. | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. | 0.456 |
FUNDC2 | CMC4 | ENSP00000358510 | ENSP00000358496 | FUN14 domain containing 2; Belongs to the FUN14 family. | Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family. | 0.594 |
FUNDC2 | CXorf56 | ENSP00000358510 | ENSP00000441786 | FUN14 domain containing 2; Belongs to the FUN14 family. | UPF0428 protein CXorf56; Chromosome X open reading frame 56. | 0.466 |
FUNDC2 | FAM162A | ENSP00000358510 | ENSP00000419088 | FUN14 domain containing 2; Belongs to the FUN14 family. | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. | 0.421 |
FUNDC2 | FUNDC1 | ENSP00000358510 | ENSP00000367284 | FUN14 domain containing 2; Belongs to the FUN14 family. | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. | 0.667 |
FUNDC2 | NDUFV2 | ENSP00000358510 | ENSP00000327268 | FUN14 domain containing 2; Belongs to the FUN14 family. | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). | 0.451 |
FUNDC2 | OCIAD1 | ENSP00000358510 | ENSP00000370882 | FUN14 domain containing 2; Belongs to the FUN14 family. | OCIA domain-containing protein 1; Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer. Belongs to the OCIAD1 family. | 0.442 |
FUNDC2 | RAB39B | ENSP00000358510 | ENSP00000358466 | FUN14 domain containing 2; Belongs to the FUN14 family. | Ras-related protein Rab-39B; Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic retic [...] | 0.423 |