STRING 10 
  IKBKG protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] (487 aa)
(Homo sapiens)
Predicted Functional Partners:
CHUK
conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the [...] (745 aa)
     0.999
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Serine kinase that [...] (756 aa)
     0.999
TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, togeth [...] (522 aa)
      0.999
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits t [...] (317 aa)
      0.999
BCL10
B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa [...] (233 aa)
      0.999
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduc [...] (671 aa)
      0.999
SUMO1
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be cova [...] (101 aa)
      0.999
CYLD
cylindromatosis (turban tumor syndrome); Protease that specifically cleaves 'Lys-63'-linked pol [...] (956 aa)
      0.999
BIRC2
baculoviral IAP repeat containing 2; Multi-functional protein which regulates not only caspases [...] (618 aa)
      0.999
UBC
ubiquitin C (685 aa)
      0.999
 
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