STRING 10 
  JPH2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
JPH2
junctophilin 2; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions (696 aa)
(Homo sapiens)
Predicted Functional Partners:
TRPC3
transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor- [...] (921 aa)
       0.859
RYR1
ryanodine receptor 1 (skeletal); Calcium channel that mediates the release of Ca(2+) from the s [...] (5038 aa)
     0.676
SMOX
spermine oxidase (555 aa)
       0.658
CAV3
caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with [...] (151 aa)
      0.624
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase (1353 aa)
      0.615
RYR2
ryanodine receptor 2 (cardiac); Calcium channel that mediates the release of Ca(2+) from the sa [...] (4967 aa)
      0.581
LMOD2
leiomodin 2 (cardiac); May block the elongation and depolymerization of the actin filaments at [...] (547 aa)
       0.553
RYR3
ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic [...] (4870 aa)
     0.476
TRDN
triadin; May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum an [...] (729 aa)
      0.472
SYPL2
synaptophysin-like 2; Involved in communication between the T-tubular and junctional sarcoplasm [...] (272 aa)
       0.472
 
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Co-expression Experiments Databases Textmining
 
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