Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTAGE8 | SLC38A10 | ENSP00000417289 | ENSP00000363891 | CTAGE family member 8. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.450 |
| KIF18A | KIF26B | ENSP00000263181 | ENSP00000385545 | Kinesin-like protein KIF18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | 0.629 |
| KIF18A | SLC38A10 | ENSP00000263181 | ENSP00000363891 | Kinesin-like protein KIF18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.413 |
| KIF26B | KIF18A | ENSP00000385545 | ENSP00000263181 | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | Kinesin-like protein KIF18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. | 0.629 |
| KIF26B | SLC38A10 | ENSP00000385545 | ENSP00000363891 | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.428 |
| MAN1B1 | SLC38A10 | ENSP00000360645 | ENSP00000363891 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.462 |
| NEK6 | SLC38A10 | ENSP00000362702 | ENSP00000363891 | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.415 |
| NPEPL1 | SLC38A10 | ENSP00000348395 | ENSP00000363891 | Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.437 |
| PRPSAP2 | SLC38A10 | ENSP00000268835 | ENSP00000363891 | Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.445 |
| SLC38A10 | CTAGE8 | ENSP00000363891 | ENSP00000417289 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | CTAGE family member 8. | 0.450 |
| SLC38A10 | KIF18A | ENSP00000363891 | ENSP00000263181 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Kinesin-like protein KIF18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. | 0.413 |
| SLC38A10 | KIF26B | ENSP00000363891 | ENSP00000385545 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | 0.428 |
| SLC38A10 | MAN1B1 | ENSP00000363891 | ENSP00000360645 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | 0.462 |
| SLC38A10 | NEK6 | ENSP00000363891 | ENSP00000362702 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. | 0.415 |
| SLC38A10 | NPEPL1 | ENSP00000363891 | ENSP00000348395 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. | 0.437 |
| SLC38A10 | PRPSAP2 | ENSP00000363891 | ENSP00000268835 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. | 0.445 |
| SLC38A10 | SLC38A9 | ENSP00000363891 | ENSP00000380074 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | 0.541 |
| SLC38A10 | TBC1D22A | ENSP00000363891 | ENSP00000336724 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.500 |
| SLC38A10 | ZNF516 | ENSP00000363891 | ENSP00000394757 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | Zinc finger protein 516; Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress. | 0.446 |
| SLC38A9 | SLC38A10 | ENSP00000380074 | ENSP00000363891 | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter. | 0.541 |
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