STRING 9.1 
  TNFRSF1B protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity (461 aa)
(Homo sapiens)
Predicted Functional Partners:
TRAF2
TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)
     0.999
TRAF1
TNF receptor-associated factor 1; Adapter protein and signal transducer that links members of t [...] (416 aa)
    0.998
DIF
Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)( [...] (233 aa)
      0.996
TNF
tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TN [...] (233 aa)
      0.986
LT
Lymphotoxin-alpha Precursor (LT-alpha)(TNF-beta)(Tumor necrosis factor ligand superfamily membe [...] (205 aa)
      0.978
ENSG00000228978
Tumor necrosis factor (TNF superfamily, member 2) Fragment (171 aa)
       0.964
BIRC2
baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with [...] (618 aa)
      0.959
BIRC3
baculoviral IAP repeat-containing 3; Apoptotic suppressor. The BIR motifs region interacts with [...] (604 aa)
      0.957
ENSG00000226979
Lymphotoxin-alpha Precursor (LT-alpha)(TNF-beta)(Tumor necrosis factor ligand superfamily membe [...] (205 aa)
      0.953
TRADD
TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically ass [...] (312 aa)
      0.950
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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