node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTRB1 | CTRB2 | ENSP00000354294 | ENSP00000303963 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | 0.949 |
CTRB1 | DNAJC1 | ENSP00000354294 | ENSP00000366179 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | 0.754 |
CTRB1 | SERPINA3 | ENSP00000354294 | ENSP00000450540 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Alpha-1-antichymotrypsin His-Pro-less; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. | 0.969 |
CTRB2 | CTRB1 | ENSP00000303963 | ENSP00000354294 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | 0.949 |
CTRB2 | DNAJC1 | ENSP00000303963 | ENSP00000366179 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | 0.767 |
CTRB2 | SERPINA3 | ENSP00000303963 | ENSP00000450540 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Alpha-1-antichymotrypsin His-Pro-less; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. | 0.971 |
DNAJC1 | CTRB1 | ENSP00000366179 | ENSP00000354294 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | 0.754 |
DNAJC1 | CTRB2 | ENSP00000366179 | ENSP00000303963 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | 0.767 |
DNAJC1 | DNAJC3 | ENSP00000366179 | ENSP00000473631 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...] | 0.662 |
DNAJC1 | HSPA12A | ENSP00000366179 | ENSP00000489674 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Heat shock 70 kDa protein 12A; Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. | 0.580 |
DNAJC1 | HSPA4 | ENSP00000366179 | ENSP00000302961 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.569 |
DNAJC1 | HSPA5 | ENSP00000366179 | ENSP00000324173 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimeriz [...] | 0.987 |
DNAJC1 | HSPA8 | ENSP00000366179 | ENSP00000437125 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.676 |
DNAJC1 | HSPA9 | ENSP00000366179 | ENSP00000297185 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity). Belongs to the heat shock protein 70 family. | 0.569 |
DNAJC1 | SEC63 | ENSP00000366179 | ENSP00000357998 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin- 1 biogenesis and trafficking to the plasma membrane of the primary [...] | 0.724 |
DNAJC1 | SERPINA3 | ENSP00000366179 | ENSP00000450540 | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | Alpha-1-antichymotrypsin His-Pro-less; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. | 0.812 |
DNAJC3 | DNAJC1 | ENSP00000473631 | ENSP00000366179 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...] | DnaJ homolog subfamily C member 1; May modulate protein synthesis. | 0.662 |
DNAJC3 | HSPA12A | ENSP00000473631 | ENSP00000489674 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...] | Heat shock 70 kDa protein 12A; Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. | 0.525 |
DNAJC3 | HSPA4 | ENSP00000473631 | ENSP00000302961 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...] | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.916 |
DNAJC3 | HSPA5 | ENSP00000473631 | ENSP00000324173 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...] | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimeriz [...] | 0.978 |