node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFP | ALPP | ENSP00000379138 | ENSP00000375881 | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | Alkaline phosphatase, placental. | 0.697 |
ALPG | ALPP | ENSP00000295453 | ENSP00000375881 | Alkaline phosphatase, germ cell. | Alkaline phosphatase, placental. | 0.791 |
ALPG | GCH1 | ENSP00000295453 | ENSP00000477796 | Alkaline phosphatase, germ cell. | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | 0.901 |
ALPG | NTPCR | ENSP00000295453 | ENSP00000355587 | Alkaline phosphatase, germ cell. | Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency. Belongs to the THEP1 NTPase family. | 0.907 |
ALPG | PTS | ENSP00000295453 | ENSP00000280362 | Alkaline phosphatase, germ cell. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.900 |
ALPG | TPK1 | ENSP00000295453 | ENSP00000353165 | Alkaline phosphatase, germ cell. | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. | 0.900 |
ALPP | AFP | ENSP00000375881 | ENSP00000379138 | Alkaline phosphatase, placental. | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | 0.697 |
ALPP | ALPG | ENSP00000375881 | ENSP00000295453 | Alkaline phosphatase, placental. | Alkaline phosphatase, germ cell. | 0.791 |
ALPP | CHRND | ENSP00000375881 | ENSP00000258385 | Alkaline phosphatase, placental. | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub- subfamily. | 0.694 |
ALPP | GCH1 | ENSP00000375881 | ENSP00000477796 | Alkaline phosphatase, placental. | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | 0.901 |
ALPP | NTPCR | ENSP00000375881 | ENSP00000355587 | Alkaline phosphatase, placental. | Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency. Belongs to the THEP1 NTPase family. | 0.902 |
ALPP | PAX3 | ENSP00000375881 | ENSP00000375921 | Alkaline phosphatase, placental. | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family. | 0.774 |
ALPP | PTS | ENSP00000375881 | ENSP00000280362 | Alkaline phosphatase, placental. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.902 |
ALPP | TPK1 | ENSP00000375881 | ENSP00000353165 | Alkaline phosphatase, placental. | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. | 0.902 |
ALPP | TRIP11 | ENSP00000375881 | ENSP00000267622 | Alkaline phosphatase, placental. | Thyroid receptor-interacting protein 11; Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. | 0.715 |
ALPP | USP49 | ENSP00000375881 | ENSP00000377797 | Alkaline phosphatase, placental. | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family. | 0.772 |
CHRND | ALPP | ENSP00000258385 | ENSP00000375881 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub- subfamily. | Alkaline phosphatase, placental. | 0.694 |
CHRND | PAX3 | ENSP00000258385 | ENSP00000375921 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub- subfamily. | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family. | 0.649 |
GCH1 | ALPG | ENSP00000477796 | ENSP00000295453 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | Alkaline phosphatase, germ cell. | 0.901 |
GCH1 | ALPP | ENSP00000477796 | ENSP00000375881 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | Alkaline phosphatase, placental. | 0.901 |