STRING 9.1 
  ARRB1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ARRB1
arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (418 aa)
(Homo sapiens)
Predicted Functional Partners:
MDM2
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
      0.996
ADRB2
adrenergic, beta-2-, receptor, surface; Beta-adrenergic receptors mediate the catecholamine- in [...] (413 aa)
     0.995
MAPK1
mitogen-activated protein kinase 1; Involved in both the initiation and regulation of meiosis, [...] (360 aa)
     0.989
ARF6
ADP-ribosylation factor 6; GTP-binding protein that functions as an allosteric activator of the [...] (175 aa)
     0.988
MAPK3
mitogen-activated protein kinase 3; Involved in both the initiation and regulation of meiosis, [...] (379 aa)
    0.987
RHO
rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for [...] (348 aa)
      0.984
ADRB1
adrenergic, beta-1-, receptor; Beta-adrenergic receptors mediate the catecholamine- induced act [...] (477 aa)
     0.975
CXCR2
chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil c [...] (360 aa)
     0.970
GRK5
G protein-coupled receptor kinase 5; Specifically phosphorylates the activated forms of G prote [...] (590 aa)
      0.970
CYTH2
cytohesin 2; Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activati [...] (399 aa)
     0.966
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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