STRINGSTRING
TMC5 TMC5 KCNH8 KCNH8 TMEM221 TMEM221 ADAMTS12 ADAMTS12 CMC1 CMC1 RNF175 RNF175 CCP110 CCP110 ANKUB1 ANKUB1 TMEM211 TMEM211 LRRC71 LRRC71 WSCD1 WSCD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
TMC5Transmembrane channel-like protein 5; Probable ion channel. (1006 aa)    
Predicted Functional Partners:
KCNH8
Potassium voltage-gated channel subfamily H member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.
   
  
 0.508
TMEM221
Transmembrane protein 221.
    
 
 0.473
ADAMTS12
A disintegrin and metalloproteinase with thrombospondin motifs 12; Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti- tumorigenic properties.
      
 0.472
CMC1
COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
      
 0.454
RNF175
Ring finger protein 175.
      
 0.435
CCP110
Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...]
      
 0.434
ANKUB1
Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1.
   
  
 0.429
TMEM211
Transmembrane protein 211.
      
 0.424
LRRC71
Leucine-rich repeat-containing protein 71; Leucine rich repeat containing 71.
   
 
 0.423
WSCD1
WSC domain containing 1.
    
 
 0.422
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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