STRING 9.1 
  TNF protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TNF
tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (233 aa)
(Homo sapiens)
Predicted Functional Partners:
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
      0.999
TRADD
TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically ass [...] (312 aa)
      0.999
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF si [...] (671 aa)
      0.998
TRAF2
TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)
      0.991
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/T [...] (461 aa)
     0.986
IL6
interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is [...] (212 aa)
      0.980
BIRC2
baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with [...] (618 aa)
     0.972
IL1B
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)
      0.971
ICAM1
intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein [...] (532 aa)
      0.969
CD40
CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG (277 aa)
      0.963
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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