CDK12 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors (1490 aa)
(Homo sapiens)
Predicted Functional Partners:
cyclin K; May play a role in transcriptional regulation. In vitro, is associated with a kinase [...] (580 aa)
suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor co [...] (1087 aa)
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyze [...] (1970 aa)
cyclin L1; Transcriptional regulator which participates in regulating the pre-mRNA splicing pro [...] (526 aa)
cyclin T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, als [...] (726 aa)
cyclin-dependent kinase 13 (1512 aa)
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; DNA-dependent RNA polymerase catalyz [...] (1390 aa)
cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member o [...] (372 aa)
cyclin T2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also [...] (730 aa)
UBX domain protein 7 (489 aa)
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network


Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

Disable Structure Previews inside Network Bubbles

 Server load: low (29%)