CDK12 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors (1490 aa)
(Homo sapiens)
Predicted Functional Partners:
cyclin K; May play a role in transcriptional regulation. In vitro, is associated with a kinase [...] (580 aa)
suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor co [...] (1087 aa)
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyze [...] (1970 aa)
cyclin L1; Transcriptional regulator which participates in regulating the pre-mRNA splicing pro [...] (526 aa)
cyclin T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, als [...] (726 aa)
cyclin-dependent kinase 13 (1512 aa)
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; DNA-dependent RNA polymerase catalyz [...] (1390 aa)
cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member o [...] (372 aa)
cyclin T2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also [...] (730 aa)
UBX domain protein 7 (489 aa)
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