STRINGSTRING
SREK1IP1 SREK1IP1 SREK1 SREK1 SMIM15 SMIM15 NUP153 NUP153 CCDC28B CCDC28B CWC27 CWC27 ZNF572 ZNF572 PRPF40A PRPF40A CREG2 CREG2 NKAPD1 NKAPD1 PPWD1 PPWD1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SREK1IP1Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. (155 aa)    
Predicted Functional Partners:
SREK1
Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).
   
  
 0.791
SMIM15
Small integral membrane protein 15.
   
  
 0.636
NUP153
Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...]
   
   0.596
CCDC28B
Coiled-coil domain-containing protein 28B; Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.
      
 0.547
CWC27
Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.
   
 
 0.528
ZNF572
Zinc finger protein 572; May be involved in transcriptional regulation.
      
 0.527
PRPF40A
Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family.
   
 
 0.521
CREG2
Protein CREG2; Cellular repressor of E1A stimulated genes 2.
      
 0.518
NKAPD1
Uncharacterized protein NKAPD1; NKAP domain containing 1.
   
   0.502
PPWD1
Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing ; Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
   
  
 0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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