STRINGSTRING
C19orf47 C19orf47 NCBP3 NCBP3 THOC1 THOC1 C19orf54 C19orf54 C15orf39 C15orf39 ZNF780A ZNF780A TTC9B TTC9B GPATCH1 GPATCH1 THOC5 THOC5 TIGD2 TIGD2 FAM124A FAM124A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C19orf47Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47. (422 aa)    
Predicted Functional Partners:
NCBP3
Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...]
   
   0.611
THOC1
THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the T [...]
    
   0.520
C19orf54
UPF0692 protein C19orf54; Chromosome 19 open reading frame 54.
   
  
 0.484
C15orf39
Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.
   
  
 0.451
ZNF780A
Zinc finger protein 780A; May be involved in transcriptional regulation.
   
 
 0.449
TTC9B
Tetratricopeptide repeat domain 9B; Belongs to the TTC9 family.
 
 
  
 0.445
GPATCH1
G-patch domain containing 1; Belongs to the GPATCH1 family.
   
  
 0.444
THOC5
THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essentia [...]
   
   0.439
TIGD2
Tigger transposable element derived 2.
   
  
 0.437
FAM124A
Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family.
   
  
 0.433
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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