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VPS52 VPS52 VPS54 VPS54 VPS53 VPS53 VPS51 VPS51 VPS50 VPS50 COG6 COG6 PDF PDF PHF3 PHF3 TINAG TINAG PTP4A1 PTP4A1 RXRB RXRB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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VPS52Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] (723 aa)    
Predicted Functional Partners:
VPS54
VPS54 subunit of GARP complex.
   
 0.987
VPS53
VPS53 subunit of GARP complex.
   
 0.986
VPS51
VPS51 subunit of GARP complex.
   
 0.979
VPS50
VPS50 subunit of EARP/GARPII complex.
   
 
 0.854
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
    
 0.816
PDF
Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family.
   
 0.814
PHF3
PHD finger protein 3.
   
  
 0.804
TINAG
Tubulointerstitial nephritis antigen; Belongs to the peptidase C1 family.
      
 0.788
PTP4A1
Protein tyrosine phosphatase 4A1.
      
 0.784
RXRB
Retinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily.
   
 
 0.783
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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