node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B2M | CALR | ENSCAFP00000047956 | ENSCAFP00000025174 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | 0.731 |
B2M | DLA88 | ENSCAFP00000047956 | ENSCAFP00000000716 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | DLA class I histocompatibility antigen, A9/A9 alpha chain; Involved in the presentation of foreign antigens to the immune system. | 0.995 |
B2M | J9P1D3_CANLF | ENSCAFP00000047956 | ENSCAFP00000039357 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Thioredoxin domain-containing protein. | 0.421 |
B2M | PDIA3 | ENSCAFP00000047956 | ENSCAFP00000019653 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Protein disulfide-isomerase. | 0.540 |
B2M | TAP1 | ENSCAFP00000047956 | ENSCAFP00000064521 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Uncharacterized protein. | 0.793 |
B2M | TAPBP | ENSCAFP00000047956 | ENSCAFP00000001381 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). | 0.811 |
CALR | B2M | ENSCAFP00000025174 | ENSCAFP00000047956 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | 0.731 |
CALR | CANX | ENSCAFP00000025174 | ENSCAFP00000000498 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | 0.958 |
CALR | DLA88 | ENSCAFP00000025174 | ENSCAFP00000000716 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | DLA class I histocompatibility antigen, A9/A9 alpha chain; Involved in the presentation of foreign antigens to the immune system. | 0.944 |
CALR | J9P1D3_CANLF | ENSCAFP00000025174 | ENSCAFP00000039357 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | Thioredoxin domain-containing protein. | 0.970 |
CALR | PDIA3 | ENSCAFP00000025174 | ENSCAFP00000019653 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | Protein disulfide-isomerase. | 0.998 |
CALR | RPA2 | ENSCAFP00000025174 | ENSCAFP00000061592 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | Replication protein A2. | 0.795 |
CALR | TAP1 | ENSCAFP00000025174 | ENSCAFP00000064521 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | Uncharacterized protein. | 0.924 |
CALR | TAPBP | ENSCAFP00000025174 | ENSCAFP00000001381 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Plays a major role in Ca2(+) storage in pancreatic cells. | Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). | 0.999 |
CALR3 | CANX | ENSCAFP00000023064 | ENSCAFP00000000498 | Calreticulin. | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | 0.884 |
CALR3 | J9P1D3_CANLF | ENSCAFP00000023064 | ENSCAFP00000039357 | Calreticulin. | Thioredoxin domain-containing protein. | 0.830 |
CALR3 | PDIA3 | ENSCAFP00000023064 | ENSCAFP00000019653 | Calreticulin. | Protein disulfide-isomerase. | 0.944 |
CALR3 | PSMB10 | ENSCAFP00000023064 | ENSCAFP00000030153 | Calreticulin. | Proteasome subunit beta. | 0.412 |
CALR3 | RPA2 | ENSCAFP00000023064 | ENSCAFP00000061592 | Calreticulin. | Replication protein A2. | 0.632 |
CALR3 | TAPBP | ENSCAFP00000023064 | ENSCAFP00000001381 | Calreticulin. | Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). | 0.902 |