node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAMK2A | CAMK2G | ENSCAFP00000059137 | ENSCAFP00000058257 | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | Calcium/calmodulin dependent protein kinase II gamma. | 0.935 |
CAMK2A | SCN1B | ENSCAFP00000059137 | ENSCAFP00000010590 | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.902 |
CAMK2A | SCN5A | ENSCAFP00000059137 | ENSCAFP00000007532 | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.923 |
CAMK2A | SCN7A | ENSCAFP00000059137 | ENSCAFP00000017137 | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.910 |
CAMK2D | SCN1B | ENSCAFP00000017868 | ENSCAFP00000010590 | Calcium/calmodulin dependent protein kinase II delta. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.902 |
CAMK2D | SCN5A | ENSCAFP00000017868 | ENSCAFP00000007532 | Calcium/calmodulin dependent protein kinase II delta. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.926 |
CAMK2D | SCN7A | ENSCAFP00000017868 | ENSCAFP00000017137 | Calcium/calmodulin dependent protein kinase II delta. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.910 |
CAMK2G | CAMK2A | ENSCAFP00000058257 | ENSCAFP00000059137 | Calcium/calmodulin dependent protein kinase II gamma. | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | 0.935 |
CAMK2G | SCN1B | ENSCAFP00000058257 | ENSCAFP00000010590 | Calcium/calmodulin dependent protein kinase II gamma. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.902 |
CAMK2G | SCN5A | ENSCAFP00000058257 | ENSCAFP00000007532 | Calcium/calmodulin dependent protein kinase II gamma. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.901 |
CAMK2G | SCN7A | ENSCAFP00000058257 | ENSCAFP00000017137 | Calcium/calmodulin dependent protein kinase II gamma. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.901 |
J9P9F2_CANLF | SCN1B | ENSCAFP00000042385 | ENSCAFP00000010590 | CaMKII_AD domain-containing protein. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.902 |
J9P9F2_CANLF | SCN5A | ENSCAFP00000042385 | ENSCAFP00000007532 | CaMKII_AD domain-containing protein. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.910 |
J9P9F2_CANLF | SCN7A | ENSCAFP00000042385 | ENSCAFP00000017137 | CaMKII_AD domain-containing protein. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.910 |
KCNQ1 | PRKACA | ENSCAFP00000063296 | ENSCAFP00000053880 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.930 |
KCNQ1 | PRKACB | ENSCAFP00000063296 | ENSCAFP00000030135 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.930 |
KCNQ1 | SCN1B | ENSCAFP00000063296 | ENSCAFP00000010590 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.519 |
KCNQ1 | SCN2B | ENSCAFP00000063296 | ENSCAFP00000042471 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. | Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). | 0.462 |
KCNQ1 | SCN5A | ENSCAFP00000063296 | ENSCAFP00000007532 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.904 |
PRKACA | KCNQ1 | ENSCAFP00000053880 | ENSCAFP00000063296 | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. | 0.930 |