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RAB5A RAB5A PIK3C3 PIK3C3 EEA1 EEA1 RABGEF1 RABGEF1 RBSN RBSN ALS2 ALS2 RIN1 RIN1 RABEP1 RABEP1 RAB5B RAB5B RAB5C RAB5C VPS45 VPS45
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)    
Predicted Functional Partners:
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
   
 0.961
EEA1
Early endosome antigen 1.
   
 0.951
RABGEF1
RAB guanine nucleotide exchange factor 1.
   
 0.941
RBSN
Rabenosyn, RAB effector.
   
 0.932
ALS2
Alsin Rho guanine nucleotide exchange factor ALS2.
   
 0.928
RIN1
Ras and Rab interactor 1.
    
 0.917
RABEP1
Rabaptin, RAB GTPase binding effector protein 1.
    
 0.914
RAB5B
RAB5B, member RAS oncogene family.
  
 
 
0.903
RAB5C
Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.
  
  
 
0.900
VPS45
Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family.
 
 
 0.868
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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