STRINGSTRING
KCNJ2 KCNJ2 KCNQ1 KCNQ1 KCNQ4 KCNQ4 KCNJ12 KCNJ12 KCNQ3 KCNQ3 KCNJ4 KCNJ4 KCNQ5 KCNQ5 KCNJ14 KCNJ14 EDNRA EDNRA GNAQ GNAQ SCN5A SCN5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...] (427 aa)    
Predicted Functional Partners:
KCNQ1
Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.
   
 
 0.987
KCNQ4
Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family.
   
 
 0.940
KCNJ12
Inward rectifier potassium channel.
  
  
0.928
KCNQ3
Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family.
   
 
 0.920
KCNJ4
Potassium voltage-gated channel subfamily J member 4.
  
  
0.917
KCNQ5
Potassium voltage-gated channel subfamily Q member 5.
   
 
 0.913
KCNJ14
Potassium voltage-gated channel subfamily J member 14.
  
  
0.904
EDNRA
Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).
   
 
 0.904
GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
   
 
 0.903
SCN5A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
   
 
 0.854
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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