node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMELX | BPIFA2 | ENSCAFP00000017046 | ENSCAFP00000010917 | Amelogenin X isoform. | BPI fold containing family A member 2. | 0.920 |
AMELX | GH1 | ENSCAFP00000017046 | ENSCAFP00000018659 | Amelogenin X isoform. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.920 |
AMELX | GHRH | ENSCAFP00000017046 | ENSCAFP00000012862 | Amelogenin X isoform. | Growth hormone releasing hormone. | 0.920 |
AMELX | GHRL | ENSCAFP00000017046 | ENSCAFP00000007641 | Amelogenin X isoform. | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | 0.655 |
AMELX | LOC478196 | ENSCAFP00000017046 | ENSCAFP00000046922 | Amelogenin X isoform. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.922 |
AMELX | PRPH2 | ENSCAFP00000017046 | ENSCAFP00000002506 | Amelogenin X isoform. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.922 |
BPIFA2 | AMELX | ENSCAFP00000010917 | ENSCAFP00000017046 | BPI fold containing family A member 2. | Amelogenin X isoform. | 0.920 |
BPIFA2 | GH1 | ENSCAFP00000010917 | ENSCAFP00000018659 | BPI fold containing family A member 2. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.920 |
BPIFA2 | GHRH | ENSCAFP00000010917 | ENSCAFP00000012862 | BPI fold containing family A member 2. | Growth hormone releasing hormone. | 0.920 |
BPIFA2 | GHRL | ENSCAFP00000010917 | ENSCAFP00000007641 | BPI fold containing family A member 2. | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | 0.487 |
BPIFA2 | LOC478196 | ENSCAFP00000010917 | ENSCAFP00000046922 | BPI fold containing family A member 2. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.920 |
BPIFA2 | PRPH2 | ENSCAFP00000010917 | ENSCAFP00000002506 | BPI fold containing family A member 2. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.918 |
EPO | GH1 | ENSCAFP00000020937 | ENSCAFP00000018659 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.917 |
EPO | GHR | ENSCAFP00000020937 | ENSCAFP00000057498 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | 0.665 |
EPO | LEP | ENSCAFP00000020937 | ENSCAFP00000002433 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.959 |
EPO | PRL | ENSCAFP00000020937 | ENSCAFP00000015048 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. | Prolactin. | 0.947 |
GH1 | AMELX | ENSCAFP00000018659 | ENSCAFP00000017046 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Amelogenin X isoform. | 0.920 |
GH1 | BPIFA2 | ENSCAFP00000018659 | ENSCAFP00000010917 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | BPI fold containing family A member 2. | 0.920 |
GH1 | EPO | ENSCAFP00000018659 | ENSCAFP00000020937 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. | 0.917 |
GH1 | GHR | ENSCAFP00000018659 | ENSCAFP00000057498 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). | 0.982 |