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HGFAC HGFAC RHOT2 RHOT2 E2RBZ7_CANLF E2RBZ7_CANLF LOC475521 LOC475521 HGF HGF SPINT1 SPINT1 SPINT4 SPINT4 SPINT2 SPINT2 MET MET PTK7 PTK7 WFDC8 WFDC8
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HGFACHepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form; Belongs to the peptidase S1 family. (723 aa)    
Predicted Functional Partners:
RHOT2
WD repeat domain 90.
   
 
 0.901
E2RBZ7_CANLF
Uncharacterized protein.
   
 
 0.837
LOC475521
Cationic trypsin.
  
 
0.835
HGF
Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.
  
0.830
SPINT1
Serine peptidase inhibitor, Kunitz type 1.
    
 
 0.800
SPINT4
Serine peptidase inhibitor, Kunitz type 4.
    
 
 0.754
SPINT2
Uncharacterized protein.
    
 
 0.719
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 
 0.690
PTK7
Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 
 0.686
WFDC8
WAP four-disulfide core domain 8.
    
 
 0.662
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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