G6PC protein (Canis lupus familiaris) - STRING interaction network

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G6PC

Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). (357 aa)

Predicted Functional Partners:

GCK

0.983

HK1

0.959

HK3

0.959

HKDC1

0.959

HK2

0.956

PGM1

0.946

GPI

0.925

GALM

0.906

G6PD

0.906

G6PC2

0.904

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G6PC	G6PC2	ENSCAFP00000021606	ENSCAFP00000017476	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.904
G6PC	G6PD	ENSCAFP00000021606	ENSCAFP00000028993	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.906
G6PC	GALM	ENSCAFP00000021606	ENSCAFP00000009394	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.	0.906
G6PC	GCK	ENSCAFP00000021606	ENSCAFP00000004364	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Phosphotransferase.	0.983
G6PC	GPI	ENSCAFP00000021606	ENSCAFP00000010874	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.925
G6PC	HK1	ENSCAFP00000021606	ENSCAFP00000020540	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase 1.	0.959
G6PC	HK2	ENSCAFP00000021606	ENSCAFP00000012208	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase 2.	0.956
G6PC	HK3	ENSCAFP00000021606	ENSCAFP00000024410	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase 3.	0.959
G6PC	HKDC1	ENSCAFP00000021606	ENSCAFP00000035961	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Hexokinase domain containing 1.	0.959
G6PC	PGM1	ENSCAFP00000021606	ENSCAFP00000057497	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family.	0.946
G6PC2	G6PC	ENSCAFP00000017476	ENSCAFP00000021606	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).	0.904
G6PC2	G6PD	ENSCAFP00000017476	ENSCAFP00000028993	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.917
G6PC2	GALM	ENSCAFP00000017476	ENSCAFP00000009394	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.	0.906
G6PC2	GCK	ENSCAFP00000017476	ENSCAFP00000004364	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Phosphotransferase.	0.980
G6PC2	GPI	ENSCAFP00000017476	ENSCAFP00000010874	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.924
G6PC2	HK1	ENSCAFP00000017476	ENSCAFP00000020540	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Hexokinase 1.	0.959
G6PC2	HK2	ENSCAFP00000017476	ENSCAFP00000012208	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Hexokinase 2.	0.959
G6PC2	HK3	ENSCAFP00000017476	ENSCAFP00000024410	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Hexokinase 3.	0.959
G6PC2	HKDC1	ENSCAFP00000017476	ENSCAFP00000035961	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Hexokinase domain containing 1.	0.959
G6PC2	PGM1	ENSCAFP00000017476	ENSCAFP00000057497	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family.	0.947

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