STRINGSTRING
ARHGAP35 ARHGAP35 RASA1 RASA1 RHOA RHOA SRC SRC THY1 THY1 ARHGAP5 ARHGAP5 RND3 RND3 RND1 RND1 RHOC RHOC RHOB RHOB CCNL1 CCNL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
ARHGAP35Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] (1516 aa)    
Predicted Functional Partners:
RASA1
RAS p21 protein activator 1.
    
 0.993
RHOA
Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...]
   
 0.955
SRC
Tyrosine-protein kinase.
   
 0.914
THY1
Ig-like domain-containing protein.
   
 
  0.902
ARHGAP5
Rho GTPase activating protein 5.
   
 
 
0.900
RND3
Rho family GTPase 3.
    
 0.788
RND1
Rho family GTPase 1.
    
 0.773
RHOC
Uncharacterized protein.
   
 0.738
RHOB
Ras homolog family member B.
    
 0.733
CCNL1
Cyclin L1; Belongs to the cyclin family.
      
 0.716
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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