node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP35 | ARHGAP5 | ENSCAFP00000036971 | ENSCAFP00000047479 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Rho GTPase activating protein 5. | 0.900 |
ARHGAP35 | CCNL1 | ENSCAFP00000036971 | ENSCAFP00000013048 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Cyclin L1; Belongs to the cyclin family. | 0.716 |
ARHGAP35 | RASA1 | ENSCAFP00000036971 | ENSCAFP00000050763 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | RAS p21 protein activator 1. | 0.993 |
ARHGAP35 | RHOA | ENSCAFP00000036971 | ENSCAFP00000030438 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.955 |
ARHGAP35 | RHOB | ENSCAFP00000036971 | ENSCAFP00000036770 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Ras homolog family member B. | 0.733 |
ARHGAP35 | RHOC | ENSCAFP00000036971 | ENSCAFP00000059310 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Uncharacterized protein. | 0.738 |
ARHGAP35 | RND1 | ENSCAFP00000036971 | ENSCAFP00000012955 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Rho family GTPase 1. | 0.773 |
ARHGAP35 | RND3 | ENSCAFP00000036971 | ENSCAFP00000040600 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Rho family GTPase 3. | 0.788 |
ARHGAP35 | SRC | ENSCAFP00000036971 | ENSCAFP00000044994 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Tyrosine-protein kinase. | 0.914 |
ARHGAP35 | THY1 | ENSCAFP00000036971 | ENSCAFP00000041761 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | Ig-like domain-containing protein. | 0.902 |
ARHGAP5 | ARHGAP35 | ENSCAFP00000047479 | ENSCAFP00000036971 | Rho GTPase activating protein 5. | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | 0.900 |
ARHGAP5 | RASA1 | ENSCAFP00000047479 | ENSCAFP00000050763 | Rho GTPase activating protein 5. | RAS p21 protein activator 1. | 0.713 |
ARHGAP5 | RHOA | ENSCAFP00000047479 | ENSCAFP00000030438 | Rho GTPase activating protein 5. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.954 |
ARHGAP5 | RHOB | ENSCAFP00000047479 | ENSCAFP00000036770 | Rho GTPase activating protein 5. | Ras homolog family member B. | 0.677 |
ARHGAP5 | RHOC | ENSCAFP00000047479 | ENSCAFP00000059310 | Rho GTPase activating protein 5. | Uncharacterized protein. | 0.677 |
ARHGAP5 | RND1 | ENSCAFP00000047479 | ENSCAFP00000012955 | Rho GTPase activating protein 5. | Rho family GTPase 1. | 0.699 |
ARHGAP5 | RND3 | ENSCAFP00000047479 | ENSCAFP00000040600 | Rho GTPase activating protein 5. | Rho family GTPase 3. | 0.914 |
ARHGAP5 | SRC | ENSCAFP00000047479 | ENSCAFP00000044994 | Rho GTPase activating protein 5. | Tyrosine-protein kinase. | 0.914 |
ARHGAP5 | THY1 | ENSCAFP00000047479 | ENSCAFP00000041761 | Rho GTPase activating protein 5. | Ig-like domain-containing protein. | 0.900 |
CCNL1 | ARHGAP35 | ENSCAFP00000013048 | ENSCAFP00000036971 | Cyclin L1; Belongs to the cyclin family. | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] | 0.716 |