node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTF | CSF3 | ENSFCAP00000049944 | ENSFCAP00000037077 | Ciliary neurotrophic factor. | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | 0.918 |
CNTF | EPO | ENSFCAP00000049944 | ENSFCAP00000006359 | Ciliary neurotrophic factor. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. | 0.919 |
CNTF | EPOR | ENSFCAP00000049944 | ENSFCAP00000004542 | Ciliary neurotrophic factor. | Erythropoietin receptor; Receptor for erythropoietin. | 0.664 |
CNTF | GH1 | ENSFCAP00000049944 | ENSFCAP00000003232 | Ciliary neurotrophic factor. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.900 |
CNTF | IL7R | ENSFCAP00000049944 | ENSFCAP00000008526 | Ciliary neurotrophic factor. | Interleukin 7 receptor. | 0.650 |
CNTF | JAK1 | ENSFCAP00000049944 | ENSFCAP00000001806 | Ciliary neurotrophic factor. | Tyrosine-protein kinase. | 0.405 |
CNTF | JAK2 | ENSFCAP00000049944 | ENSFCAP00000049673 | Ciliary neurotrophic factor. | Tyrosine-protein kinase. | 0.492 |
CNTF | JAK3 | ENSFCAP00000049944 | ENSFCAP00000006963 | Ciliary neurotrophic factor. | Tyrosine-protein kinase. | 0.413 |
CNTF | LEP | ENSFCAP00000049944 | ENSFCAP00000033061 | Ciliary neurotrophic factor. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.934 |
CNTF | PRL | ENSFCAP00000049944 | ENSFCAP00000013943 | Ciliary neurotrophic factor. | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. | 0.903 |
CSF3 | CNTF | ENSFCAP00000037077 | ENSFCAP00000049944 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Ciliary neurotrophic factor. | 0.918 |
CSF3 | EPO | ENSFCAP00000037077 | ENSFCAP00000006359 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. | 0.954 |
CSF3 | EPOR | ENSFCAP00000037077 | ENSFCAP00000004542 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Erythropoietin receptor; Receptor for erythropoietin. | 0.709 |
CSF3 | GH1 | ENSFCAP00000037077 | ENSFCAP00000003232 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.903 |
CSF3 | IL7R | ENSFCAP00000037077 | ENSFCAP00000008526 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Interleukin 7 receptor. | 0.678 |
CSF3 | JAK1 | ENSFCAP00000037077 | ENSFCAP00000001806 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Tyrosine-protein kinase. | 0.842 |
CSF3 | JAK2 | ENSFCAP00000037077 | ENSFCAP00000049673 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Tyrosine-protein kinase. | 0.886 |
CSF3 | JAK3 | ENSFCAP00000037077 | ENSFCAP00000006963 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Tyrosine-protein kinase. | 0.818 |
CSF3 | LEP | ENSFCAP00000037077 | ENSFCAP00000033061 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.941 |
CSF3 | PRL | ENSFCAP00000037077 | ENSFCAP00000013943 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. | 0.904 |