DERL2 protein (Homo sapiens) - STRING network view

STRING 9.05

DERL2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	DERL2	Der1-like domain family, member 2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell prolif [...] (239 aa)
		(Homo sapiens)
Predicted Functional Partners:
	AMFR	autocrine motility factor receptor; Specific receptor for the autocrine motility factor. Posses [...] (643 aa)		•	•	•	0.971
	SYVN1	synovial apoptosis inhibitor 1, synoviolin; Acts as an E3 ubiquitin-protein ligase which accept [...] (617 aa)		•		•	0.965
	VCP	valosin-containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and [...] (806 aa)		•		•	0.965
	SELS	Selenoprotein S (SelS)(VCP-interacting membrane protein); Involved in the degradation process o [...] (188 aa)	•	•	•	•	0.932
	UBE2J1	Ubiquitin-conjugating enzyme E2 J1 (EC 6.3.2.19)(Non-canonical ubiquitin-conjugating enzyme 1)( [...] (318 aa)	•	•		•	0.916
	FAF2	Fas associated factor family member 2; May play a role in the translocation of terminally misfo [...] (445 aa)		•		•	0.916
	SEL1L	sel-1 suppressor of lin-12-like (C. elegans); May play a role in Notch signaling (By similarity [...] (794 aa)		•		•	0.914
	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Inhibitor [...] (418 aa)		•			0.846
	HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilit [...] (654 aa)	•			•	0.807
	ENSG00000227277	E3 ubiquitin-protein ligase RNF5 (EC 6.3.2.-)(RING finger protein 5)(HsRma1)(Protein G16) (182 aa)			•		0.800

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Co-expression Experiments Databases Textmining

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