node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMA1 | KITLG | ENSECAP00000021840 | ENSECAP00000000163 | Chymase 1; Belongs to the peptidase S1 family. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.919 |
CMA1 | MMP9 | ENSECAP00000021840 | ENSECAP00000011232 | Chymase 1; Belongs to the peptidase S1 family. | Matrix metallopeptidase 9. | 0.532 |
CSF1R | EGFR | ENSECAP00000002580 | ENSECAP00000035347 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Receptor protein-tyrosine kinase. | 0.533 |
CSF1R | KITLG | ENSECAP00000002580 | ENSECAP00000000163 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.959 |
EGFR | CSF1R | ENSECAP00000035347 | ENSECAP00000002580 | Receptor protein-tyrosine kinase. | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.533 |
EGFR | FLT3 | ENSECAP00000035347 | ENSECAP00000052872 | Receptor protein-tyrosine kinase. | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.446 |
EGFR | INSR | ENSECAP00000035347 | ENSECAP00000008032 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.488 |
EGFR | KITLG | ENSECAP00000035347 | ENSECAP00000000163 | Receptor protein-tyrosine kinase. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.931 |
EGFR | MMP9 | ENSECAP00000035347 | ENSECAP00000011232 | Receptor protein-tyrosine kinase. | Matrix metallopeptidase 9. | 0.749 |
EGFR | PDGFRA | ENSECAP00000035347 | ENSECAP00000043405 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.961 |
EGFR | PDGFRB | ENSECAP00000035347 | ENSECAP00000022400 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.964 |
EGFR | THPO | ENSECAP00000035347 | ENSECAP00000004295 | Receptor protein-tyrosine kinase. | Thrombopoietin. | 0.652 |
FLT3 | EGFR | ENSECAP00000052872 | ENSECAP00000035347 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Receptor protein-tyrosine kinase. | 0.446 |
FLT3 | KITLG | ENSECAP00000052872 | ENSECAP00000000163 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.946 |
FLT3 | PDGFRB | ENSECAP00000052872 | ENSECAP00000022400 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.794 |
FLT3 | THPO | ENSECAP00000052872 | ENSECAP00000004295 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Thrombopoietin. | 0.647 |
INSR | EGFR | ENSECAP00000008032 | ENSECAP00000035347 | Tyrosine-protein kinase receptor. | Receptor protein-tyrosine kinase. | 0.488 |
INSR | KITLG | ENSECAP00000008032 | ENSECAP00000000163 | Tyrosine-protein kinase receptor. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.922 |
KIT | KITLG | ENSECAP00000011188 | ENSECAP00000000163 | KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | 0.999 |
KITLG | CMA1 | ENSECAP00000000163 | ENSECAP00000021840 | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. | Chymase 1; Belongs to the peptidase S1 family. | 0.919 |