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S100A6 S100A6 CACYBP CACYBP S100A10 S100A10 S100A11 S100A11 S100A13 S100A13 AGER AGER ANXA1 ANXA1 S100A16 S100A16 S100A12 S100A12 SIAH1 SIAH1 S100A4 S100A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
S100A6Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (92 aa)    
Predicted Functional Partners:
CACYBP
Calcyclin binding protein.
   
 
 0.967
S100A10
S100 calcium binding protein A10; Belongs to the S-100 family.
   
 0.883
S100A11
Protein S100; Belongs to the S-100 family.
   
 
 0.837
S100A13
S100 calcium binding protein A13; Belongs to the S-100 family.
   
  
 0.773
AGER
Advanced glycosylation end-product specific receptor.
    
 0.765
ANXA1
Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]
   
 
 0.745
S100A16
Protein S100; Belongs to the S-100 family.
   
 
 0.742
S100A12
Protein S100; Belongs to the S-100 family.
   
 
0.724
SIAH1
E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
    
 0.708
S100A4
Protein S100; Belongs to the S-100 family.
  
 
0.700
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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