STRINGSTRING
ASZ1 ASZ1 PLD6 PLD6 FKBP6 FKBP6 BOLL BOLL REPIN1 REPIN1 DBT DBT RBBP8 RBBP8 DDX4 DDX4 SPATA22 SPATA22 CTCFL CTCFL PIWIL2 PIWIL2
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ASZ1Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] (475 aa)    
Predicted Functional Partners:
PLD6
Phospholipase D family member 6.
   
  
 0.865
FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6; Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be re [...]
   
 0.850
BOLL
Boule homolog, RNA binding protein.
   
 
 0.816
REPIN1
Replication initiator 1.
    
 0.779
DBT
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
   
 0.743
RBBP8
RB binding protein 8, endonuclease.
   
 0.735
DDX4
DEAD-box helicase 4; Belongs to the DEAD box helicase family.
   
 0.725
SPATA22
Spermatogenesis associated 22.
   
  
 0.715
CTCFL
CCCTC-binding factor like.
    
 0.714
PIWIL2
Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family.
   
 0.686
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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