STRINGSTRING
IL12B IL12B IL23A IL23A IL12A IL12A IL12RB1 IL12RB1 IL12RB2 IL12RB2 IL23R IL23R P4HB P4HB IL2RA IL2RA IFNGR1 IFNGR1 IL27RA IL27RA IL6ST IL6ST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)    
Predicted Functional Partners:
IL23A
Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...]
  
 0.996
IL12A
Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
    
 0.995
IL12RB1
Interleukin 12 receptor subunit beta 1.
    
 0.990
IL12RB2
Interleukin 12 receptor subunit beta 2.
   
 
 0.971
IL23R
Interleukin 23 receptor.
   
 0.962
P4HB
Protein disulfide-isomerase.
   
  0.804
IL2RA
Interleukin 2 receptor subunit alpha.
  
 
 0.800
IFNGR1
Interferon gamma receptor 1.
  
  
 0.783
IL27RA
Interleukin 27 receptor subunit alpha.
   
 
 0.767
IL6ST
Interleukin 6 signal transducer.
   
 
 0.758
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (24%) [HD]