node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BCL2 | ENSECAP00000022364 | ENSECAP00000037719 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 apoptosis regulator. | 0.945 |
APAF1 | CASP3 | ENSECAP00000022364 | ENSECAP00000019797 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase-3-like protein; Belongs to the peptidase C14A family. | 0.997 |
APAF1 | CASP9 | ENSECAP00000022364 | ENSECAP00000039254 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 9; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CYC1 | ENSECAP00000022364 | ENSECAP00000018094 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c1. | 0.445 |
APAF1 | CYCS | ENSECAP00000022364 | ENSECAP00000012031 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.999 |
BCL2 | APAF1 | ENSECAP00000037719 | ENSECAP00000022364 | BCL2 apoptosis regulator. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.945 |
BCL2 | CASP3 | ENSECAP00000037719 | ENSECAP00000019797 | BCL2 apoptosis regulator. | Caspase-3-like protein; Belongs to the peptidase C14A family. | 0.974 |
BCL2 | CASP9 | ENSECAP00000037719 | ENSECAP00000039254 | BCL2 apoptosis regulator. | Caspase 9; Belongs to the peptidase C14A family. | 0.969 |
BCL2 | CYCS | ENSECAP00000037719 | ENSECAP00000012031 | BCL2 apoptosis regulator. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.988 |
BCL2 | VDAC2 | ENSECAP00000037719 | ENSECAP00000013147 | BCL2 apoptosis regulator. | Voltage dependent anion channel 2. | 0.678 |
CASP3 | APAF1 | ENSECAP00000019797 | ENSECAP00000022364 | Caspase-3-like protein; Belongs to the peptidase C14A family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.997 |
CASP3 | BCL2 | ENSECAP00000019797 | ENSECAP00000037719 | Caspase-3-like protein; Belongs to the peptidase C14A family. | BCL2 apoptosis regulator. | 0.974 |
CASP3 | CASP9 | ENSECAP00000019797 | ENSECAP00000039254 | Caspase-3-like protein; Belongs to the peptidase C14A family. | Caspase 9; Belongs to the peptidase C14A family. | 0.986 |
CASP3 | CYCS | ENSECAP00000019797 | ENSECAP00000012031 | Caspase-3-like protein; Belongs to the peptidase C14A family. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.998 |
CASP9 | APAF1 | ENSECAP00000039254 | ENSECAP00000022364 | Caspase 9; Belongs to the peptidase C14A family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.999 |
CASP9 | BCL2 | ENSECAP00000039254 | ENSECAP00000037719 | Caspase 9; Belongs to the peptidase C14A family. | BCL2 apoptosis regulator. | 0.969 |
CASP9 | CASP3 | ENSECAP00000039254 | ENSECAP00000019797 | Caspase 9; Belongs to the peptidase C14A family. | Caspase-3-like protein; Belongs to the peptidase C14A family. | 0.986 |
CASP9 | CYCS | ENSECAP00000039254 | ENSECAP00000012031 | Caspase 9; Belongs to the peptidase C14A family. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.999 |
COX1 | COX2 | ENSECAP00000023107 | ENSECAP00000023106 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | 0.999 |
COX1 | CYC1 | ENSECAP00000023107 | ENSECAP00000018094 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | Cytochrome c1. | 0.999 |