STRINGSTRING
IL23A IL23A IL12B IL12B IL23R IL23R IL12RB1 IL12RB1 TYK2 TYK2 JAK2 JAK2 IL17A IL17A IL4R IL4R IL12RB2 IL12RB2 IFNGR2 IFNGR2 IL22RA1 IL22RA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa)    
Predicted Functional Partners:
IL12B
Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family.
  
 0.996
IL23R
Interleukin 23 receptor.
   
 0.996
IL12RB1
Interleukin 12 receptor subunit beta 1.
   
 0.988
TYK2
Tyrosine-protein kinase.
     
 0.957
JAK2
Tyrosine-protein kinase.
     
 0.955
IL17A
Uncharacterized protein.
   
 
 0.796
IL4R
Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).
  
  
 0.755
IL12RB2
Interleukin 12 receptor subunit beta 2.
   
 
 0.753
IFNGR2
Interferon gamma receptor 2.
  
  
 0.746
IL22RA1
Interleukin 22 receptor subunit alpha 1.
  
  
 0.741
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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