node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCN | EGFR | ENSSSCP00000000977 | ENSSSCP00000068369 | Decorin; May affect the rate of fibrils formation. | Receptor protein-tyrosine kinase. | 0.964 |
DCN | IGF1 | ENSSSCP00000000977 | ENSSSCP00000000915 | Decorin; May affect the rate of fibrils formation. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.966 |
DCN | LUM | ENSSSCP00000000977 | ENSSSCP00000000978 | Decorin; May affect the rate of fibrils formation. | Lumican. | 0.937 |
DCN | MET | ENSSSCP00000000977 | ENSSSCP00000017620 | Decorin; May affect the rate of fibrils formation. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.937 |
DCN | MMP2 | ENSSSCP00000000977 | ENSSSCP00000073458 | Decorin; May affect the rate of fibrils formation. | Uncharacterized protein. | 0.944 |
DCN | TGFB1 | ENSSSCP00000000977 | ENSSSCP00000030317 | Decorin; May affect the rate of fibrils formation. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.992 |
DCN | TGFB2 | ENSSSCP00000000977 | ENSSSCP00000035439 | Decorin; May affect the rate of fibrils formation. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.949 |
DCN | TGFB3 | ENSSSCP00000000977 | ENSSSCP00000030885 | Decorin; May affect the rate of fibrils formation. | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.958 |
DCN | TLR2 | ENSSSCP00000000977 | ENSSSCP00000067954 | Decorin; May affect the rate of fibrils formation. | Toll-like receptor 2; Belongs to the Toll-like receptor family. | 0.946 |
DCN | TLR4 | ENSSSCP00000000977 | ENSSSCP00000060828 | Decorin; May affect the rate of fibrils formation. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.961 |
EGFR | DCN | ENSSSCP00000068369 | ENSSSCP00000000977 | Receptor protein-tyrosine kinase. | Decorin; May affect the rate of fibrils formation. | 0.964 |
EGFR | IGF1 | ENSSSCP00000068369 | ENSSSCP00000000915 | Receptor protein-tyrosine kinase. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.962 |
EGFR | MET | ENSSSCP00000068369 | ENSSSCP00000017620 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.781 |
EGFR | MMP2 | ENSSSCP00000068369 | ENSSSCP00000073458 | Receptor protein-tyrosine kinase. | Uncharacterized protein. | 0.590 |
EGFR | TGFB1 | ENSSSCP00000068369 | ENSSSCP00000030317 | Receptor protein-tyrosine kinase. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.700 |
EGFR | TGFB2 | ENSSSCP00000068369 | ENSSSCP00000035439 | Receptor protein-tyrosine kinase. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.408 |
EGFR | TLR2 | ENSSSCP00000068369 | ENSSSCP00000067954 | Receptor protein-tyrosine kinase. | Toll-like receptor 2; Belongs to the Toll-like receptor family. | 0.492 |
EGFR | TLR4 | ENSSSCP00000068369 | ENSSSCP00000060828 | Receptor protein-tyrosine kinase. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.495 |
IGF1 | DCN | ENSSSCP00000000915 | ENSSSCP00000000977 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | Decorin; May affect the rate of fibrils formation. | 0.966 |
IGF1 | EGFR | ENSSSCP00000000915 | ENSSSCP00000068369 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | Receptor protein-tyrosine kinase. | 0.962 |