STRINGSTRING
SERPINB1 SERPINB1 ECM2 ECM2 LOC100154047 LOC100154047 LOC100521229 LOC100521229 S100A12 S100A12 CNDP2 CNDP2 CAPS CAPS LOC110261434 LOC110261434 PRTN3 PRTN3 I3LP35_PIG I3LP35_PIG HMGB2 HMGB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SERPINB1Leukocyte elastase inhibitor; Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a [...] (413 aa)    
Predicted Functional Partners:
ECM2
Extracellular matrix protein 2.
   
  
 0.597
LOC100154047
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
    
 
 0.587
LOC100521229
Alkaline phosphatase.
      
 0.550
S100A12
Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...]
   
 0.537
CNDP2
Cytosolic non-specific dipeptidase isoform X1.
   
  
 0.529
CAPS
Calcyphosin isoform a.
   
  
 0.505
LOC110261434
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
    
 
 0.502
PRTN3
Proteinase 3; Belongs to the peptidase S1 family.
    
 
 0.498
I3LP35_PIG
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
    
 
 0.493
HMGB2
High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...]
      
 0.491
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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