STRINGSTRING
CRYBB1 CRYBB1 GJA3 GJA3 GJA8 GJA8 CRYAA CRYAA BFSP2 BFSP2 RPUSD4 RPUSD4 ITSN2 ITSN2 CRYAB CRYAB HSF4 HSF4 ITSN1 ITSN1 PITX3 PITX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CRYBB1Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family. (249 aa)    
Predicted Functional Partners:
GJA3
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  
  
 0.797
GJA8
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
  
 0.793
CRYAA
Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
   
  
 0.729
BFSP2
Beaded filament structural protein 2; Belongs to the intermediate filament family.
    
 
 0.725
RPUSD4
RNA pseudouridylate synthase domain-containing protein 4.
    
 
 0.676
ITSN2
Intersectin 2.
   
 
 0.640
CRYAB
Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
   
  
 0.624
HSF4
Heat shock transcription factor 4.
      
 0.605
ITSN1
Intersectin 1.
    
 
 0.604
PITX3
Homeobox protein.
      
 0.599
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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