STRINGSTRING
SPCS1 SPCS1 SPCS2 SPCS2 SPCS3 SPCS3 SEC11A SEC11A SEC11C SEC11C DAD1 DAD1 SRP54 SRP54 SEC63 SEC63 SRP19 SRP19 GRP GRP SRP9 SRP9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SPCS1Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (214 aa)    
Predicted Functional Partners:
SPCS2
Signal peptidase complex subunit 2.
   
 0.995
SPCS3
Signal peptidase complex subunit 3.
   
 0.988
SEC11A
Signal peptidase complex catalytic subunit SEC11.
   
 0.931
SEC11C
Signal peptidase complex catalytic subunit SEC11.
   
 0.924
DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]
   
  
 0.806
SRP54
Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.
   
  
 0.791
SEC63
SEC63 homolog, protein translocation regulator.
    
 
 0.781
SRP19
Signal recognition particle 19 kDa protein isoform 1.
   
  
 0.769
GRP
Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family.
   
 
 0.766
SRP9
Signal recognition particle 9.
   
  
 0.755
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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