STRINGSTRING
DNASE2 DNASE2 TMPRSS9 TMPRSS9 DNASE1 DNASE1 SPATA48 SPATA48 DNASE1L3 DNASE1L3 RNASEH2A RNASEH2A SKIV2L SKIV2L RNASEH2C RNASEH2C DNASE1L1 DNASE1L1 CTSZ CTSZ FIGNL1 FIGNL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
DNASE2Deoxyribonuclease-2-alpha; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (By similarity); Belongs to the DNase II family. (363 aa)    
Predicted Functional Partners:
TMPRSS9
Transmembrane serine protease 9; Belongs to the peptidase S1 family.
   
  
 0.865
DNASE1
Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By s [...]
   
  
 0.862
SPATA48
Spermatogenesis associated 48.
      
 0.820
DNASE1L3
Deoxyribonuclease; Belongs to the DNase I family.
      
 0.690
RNASEH2A
Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
   
  
 0.675
SKIV2L
Ski2 like RNA helicase.
      
 0.662
RNASEH2C
Ribonuclease H2 subunit C.
      
 0.652
DNASE1L1
Deoxyribonuclease-1-like 1.
   
  
 0.649
CTSZ
Cathepsin Z; Belongs to the peptidase C1 family.
   
 
 0.626
FIGNL1
Fidgetin-like protein 1 isoform 1; Belongs to the AAA ATPase family.
   
 
 0.624
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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