STRINGSTRING
SFXN1 SFXN1 MTRF1 MTRF1 RUNX1T1 RUNX1T1 FBXL4 FBXL4 MCHR2 MCHR2 N6AMT1 N6AMT1 TUSC5 TUSC5 LEPROT LEPROT DNAJC6 DNAJC6 MAP3K6 MAP3K6 GUCY1A2 GUCY1A2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SFXN1Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D- serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs t [...] (322 aa)    
Predicted Functional Partners:
MTRF1
Mitochondrial translation release factor 1.
   
  
 0.671
RUNX1T1
RUNX1 partner transcriptional co-repressor 1.
   
    0.640
FBXL4
F-box and leucine-rich repeat protein 4.
   
  
 0.625
MCHR2
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
      
 0.611
N6AMT1
N-6 adenine-specific DNA methyltransferase 1.
   
  
 0.605
TUSC5
Uncharacterized protein.
      
 0.599
LEPROT
Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity).
    
 
 0.582
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6.
      
 0.543
MAP3K6
Mitogen-activated protein kinase kinase kinase 6.
      
 0.531
GUCY1A2
Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
   
  
 0.528
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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