node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC6 | FBXL4 | ENSSSCP00000035340 | ENSSSCP00000004691 | DnaJ heat shock protein family (Hsp40) member C6. | F-box and leucine-rich repeat protein 4. | 0.545 |
DNAJC6 | LEPROT | ENSSSCP00000035340 | ENSSSCP00000062516 | DnaJ heat shock protein family (Hsp40) member C6. | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). | 0.740 |
DNAJC6 | MCHR2 | ENSSSCP00000035340 | ENSSSCP00000004699 | DnaJ heat shock protein family (Hsp40) member C6. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.544 |
DNAJC6 | MTRF1 | ENSSSCP00000035340 | ENSSSCP00000010075 | DnaJ heat shock protein family (Hsp40) member C6. | Mitochondrial translation release factor 1. | 0.696 |
DNAJC6 | SFXN1 | ENSSSCP00000035340 | ENSSSCP00000014954 | DnaJ heat shock protein family (Hsp40) member C6. | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D- serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs t [...] | 0.543 |
FBXL4 | DNAJC6 | ENSSSCP00000004691 | ENSSSCP00000035340 | F-box and leucine-rich repeat protein 4. | DnaJ heat shock protein family (Hsp40) member C6. | 0.545 |
FBXL4 | LEPROT | ENSSSCP00000004691 | ENSSSCP00000062516 | F-box and leucine-rich repeat protein 4. | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). | 0.627 |
FBXL4 | MCHR2 | ENSSSCP00000004691 | ENSSSCP00000004699 | F-box and leucine-rich repeat protein 4. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.678 |
FBXL4 | MTRF1 | ENSSSCP00000004691 | ENSSSCP00000010075 | F-box and leucine-rich repeat protein 4. | Mitochondrial translation release factor 1. | 0.662 |
FBXL4 | N6AMT1 | ENSSSCP00000004691 | ENSSSCP00000020458 | F-box and leucine-rich repeat protein 4. | N-6 adenine-specific DNA methyltransferase 1. | 0.639 |
FBXL4 | SFXN1 | ENSSSCP00000004691 | ENSSSCP00000014954 | F-box and leucine-rich repeat protein 4. | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D- serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs t [...] | 0.625 |
GUCY1A2 | SFXN1 | ENSSSCP00000020697 | ENSSSCP00000014954 | Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D- serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs t [...] | 0.528 |
LEPROT | DNAJC6 | ENSSSCP00000062516 | ENSSSCP00000035340 | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). | DnaJ heat shock protein family (Hsp40) member C6. | 0.740 |
LEPROT | FBXL4 | ENSSSCP00000062516 | ENSSSCP00000004691 | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). | F-box and leucine-rich repeat protein 4. | 0.627 |
LEPROT | MCHR2 | ENSSSCP00000062516 | ENSSSCP00000004699 | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.668 |
LEPROT | MTRF1 | ENSSSCP00000062516 | ENSSSCP00000010075 | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). | Mitochondrial translation release factor 1. | 0.653 |
LEPROT | SFXN1 | ENSSSCP00000062516 | ENSSSCP00000014954 | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D- serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs t [...] | 0.582 |
MAP3K6 | SFXN1 | ENSSSCP00000028861 | ENSSSCP00000014954 | Mitogen-activated protein kinase kinase kinase 6. | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D- serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs t [...] | 0.531 |
MAP3K6 | TUSC5 | ENSSSCP00000028861 | ENSSSCP00000018859 | Mitogen-activated protein kinase kinase kinase 6. | Uncharacterized protein. | 0.543 |
MCHR2 | DNAJC6 | ENSSSCP00000004699 | ENSSSCP00000035340 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | DnaJ heat shock protein family (Hsp40) member C6. | 0.544 |