node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | BGN | ENSSSCP00000052661 | ENSSSCP00000029666 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Biglycan; May be involved in collagen fiber assembly. | 0.899 |
ACAN | COMP | ENSSSCP00000052661 | ENSSSCP00000014796 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Cartilage oligomeric matrix protein. | 0.945 |
ACAN | DCN | ENSSSCP00000052661 | ENSSSCP00000000977 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Decorin; May affect the rate of fibrils formation. | 0.926 |
ACAN | FMOD | ENSSSCP00000052661 | ENSSSCP00000016193 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). | 0.918 |
ACAN | LUM | ENSSSCP00000052661 | ENSSSCP00000000978 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Lumican. | 0.824 |
ACAN | OGN | ENSSSCP00000052661 | ENSSSCP00000045106 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Osteoglycin/mimecan. | 0.650 |
ACAN | TGFB1 | ENSSSCP00000052661 | ENSSSCP00000030317 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.746 |
ACAN | TGFB2 | ENSSSCP00000052661 | ENSSSCP00000035439 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.464 |
ACAN | TGFB3 | ENSSSCP00000052661 | ENSSSCP00000030885 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.748 |
ACAN | TNMD | ENSSSCP00000052661 | ENSSSCP00000013275 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenomodulin. | 0.639 |
BGN | ACAN | ENSSSCP00000029666 | ENSSSCP00000052661 | Biglycan; May be involved in collagen fiber assembly. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.899 |
BGN | COMP | ENSSSCP00000029666 | ENSSSCP00000014796 | Biglycan; May be involved in collagen fiber assembly. | Cartilage oligomeric matrix protein. | 0.705 |
BGN | DCN | ENSSSCP00000029666 | ENSSSCP00000000977 | Biglycan; May be involved in collagen fiber assembly. | Decorin; May affect the rate of fibrils formation. | 0.876 |
BGN | FMOD | ENSSSCP00000029666 | ENSSSCP00000016193 | Biglycan; May be involved in collagen fiber assembly. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). | 0.801 |
BGN | LUM | ENSSSCP00000029666 | ENSSSCP00000000978 | Biglycan; May be involved in collagen fiber assembly. | Lumican. | 0.617 |
BGN | OGN | ENSSSCP00000029666 | ENSSSCP00000045106 | Biglycan; May be involved in collagen fiber assembly. | Osteoglycin/mimecan. | 0.572 |
BGN | TGFB1 | ENSSSCP00000029666 | ENSSSCP00000030317 | Biglycan; May be involved in collagen fiber assembly. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.778 |
BGN | TGFB3 | ENSSSCP00000029666 | ENSSSCP00000030885 | Biglycan; May be involved in collagen fiber assembly. | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.611 |
BGN | TNMD | ENSSSCP00000029666 | ENSSSCP00000013275 | Biglycan; May be involved in collagen fiber assembly. | Tenomodulin. | 0.760 |
COMP | ACAN | ENSSSCP00000014796 | ENSSSCP00000052661 | Cartilage oligomeric matrix protein. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.945 |